As a continuation of their investigate to improve the cellular action of strike compound 100 bearing an indazole scaffold, a series of new compounds harnessing fluorine substituents were designed, synthesized and evaluated as inhibitors of the above enzyme by Li et al.This product or service may perhaps consist of inactive elements, which often can
The indazole scaffold represents a promising pharmacophore, commonly incorporated in a number of therapeutic drugs. Though indazole-containing drugs are regularly promoted as being the corresponding NSo that you can rationalise the observed ABL kinase inhibitory success from a 3D structural point of view, the lead compounds I and II, as well as new
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